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Dual Color Imaging from a Single BF2-Azadipyrromethene Fluorophore Demonstrated in vivo for Lymph Node Identification

preprint
submitted on 07.11.2020, 10:28 and posted on 09.11.2020, 11:07 by Niamh Curtin, Dan Wu, Ronan A. Cahill, Anwesha Sarkar, Pól Mac Aonghusa, Sergiy Zhuk, Manuel Barberio, Mahdi Al-Taher, Jacques Marescaux, Michele Diana, Donal O'Shea

Dual color fluorescence imaging has been achieved in the highly complex biomedical scenario of lymph node mapping. Emissions at 700 and 800 nm can be achieved from a single fluorophore by establishing molecular and aggregate forms. Fluorophore was compatible with clinical systems for fluorescence guided surgery and no toxicity was observed in high dosage testing.

Funding

This work was supported with funding support from the Irish Government Department of Business, Enterprise and Innovation’s Disruptive Technology Innovation Fund. DOS gratefully acknowledges Science Foundation Ireland grant number 17/TIDA/4936 and AMBER 12/RC/2278 P2 for financial support. MD acknowledges additional funding provided by the ARC Foundation (https://www.fondation-arc.org/), via the ELIOS grant.

History

Email Address of Submitting Author

donalfoshea@rcsi.ie

Institution

RCSI

Country

Ireland

ORCID For Submitting Author

0000-0003-0594-4193

Declaration of Conflict of Interest

DFOS has a financial interest in patents filed and granted relating to NIR-fluorophores and processes for visual determination of tissue biology. RC is named on a patent filed in relation to processes for visual determination of tissue biology and receives speaker fees from Stryker Corp, consultancy fees from Distal Motion and holds research funding from Intuitive Corp and with IBM Corp and Deciphex. PMA, SZ are full-time employees of IBM Research, a division of IBM Corporation. IBM Corporation provides technical products and services world-wide to government, healthcare and life-sciences companies. PMA, SZ hold and have filed patents concerning technologies related to the subject matter of this paper. MD is member of the Advisory Board of Diagnostic Green and is the recipient of the ELIOS grant from the ARC Foundation. JM is the President of the IRCAD Institute, which is partly funded by KARL STORZ and Medtronic.

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