Dual color fluorescence imaging has been
achieved in the highly complex biomedical scenario of lymph node mapping. Emissions at 700 and 800 nm can be achieved
from a single fluorophore by establishing molecular and aggregate forms. Fluorophore was compatible with clinical
systems for fluorescence guided surgery and no toxicity was observed in high
This work was supported with funding support from the Irish Government Department of Business, Enterprise and Innovation’s Disruptive Technology Innovation Fund. DOS gratefully acknowledges Science Foundation Ireland grant number 17/TIDA/4936 and AMBER 12/RC/2278 P2 for ﬁnancial support. MD acknowledges additional funding provided by the ARC Foundation (https://www.fondation-arc.org/), via the ELIOS grant.
ORCID For Submitting Author0000-0003-0594-4193
Declaration of Conflict of InterestDFOS has a financial interest in patents filed and granted relating to NIR-fluorophores and processes for visual determination of tissue biology. RC is named on a patent filed in relation to processes for visual determination of tissue biology and receives speaker fees from Stryker Corp, consultancy fees from Distal Motion and holds research funding from Intuitive Corp and with IBM Corp and Deciphex. PMA, SZ are full-time employees of IBM Research, a division of IBM Corporation. IBM Corporation provides technical products and services world-wide to government, healthcare and life-sciences companies. PMA, SZ hold and have filed patents concerning technologies related to the subject matter of this paper. MD is member of the Advisory Board of Diagnostic Green and is the recipient of the ELIOS grant from the ARC Foundation. JM is the President of the IRCAD Institute, which is partly funded by KARL STORZ and Medtronic.