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Dual Cobalt and Photoredox Catalysis Enabled Intermolecular Oxidative Hydrofunctionalization

preprint
submitted on 24.02.2020 and posted on 25.02.2020 by Han-Li Sun, Fan Yang, Wei-Ting Ye, Jun-Jie Wang, Rong Zhu
A general protocol has been developed for the Markovnikov-selective intermolecular hydrofunctionalization based on visible-light-mediated Co/Ru dual catalysis. The key feature involves the photochemical oxidation of an organocobalt(III) intermediate derived from hydrogen atom transfer, which is supported by electrochemical analysis, quenching studies and stoichiometric experiments. This unique redox process enables the efficient branch-selective alkylation of pharmaceutically important nucleophiles (phenols, sulfonamides and various N-heterocycles) using a wide range of alkenes including moderately electron-deficient ones. Moreover, light-gated polar functionalization via organocobalt species was demonstrated.

History

Email Address of Submitting Author

rongzhu@pku.edu.cn

Institution

Peking University

Country

China

ORCID For Submitting Author

0000-0001-5035-3531

Declaration of Conflict of Interest

no conflict of interest

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