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Drug induced micellization into ultra-high capacity and stable curcumin nanoformulations: Comparing in vitro 2D and 3D-tumor model of triple-negative breast cancer

preprint
submitted on 03.12.2017 and posted on 05.12.2017 by Michael M. Lübtow, Lena C. Nelke, Anna Brown, Gaurav Sahay, Gudrun Dandekar, Robert Luxenhofer
This manuscript describes a ultra-high loaded nanoformulation of curcumin. This compound is extremely water insoluble but could be dissolved using poly(2-oxazoline)/poly(2-oxazine) based polymer amphiphiles. The resulting formulations were thoroughly characterized in solution and solid form by NMR, dynamic light scattering, electron microscopy, HPLC zeta potential measurements, XRD, respectively. Biological activity was ensured and compared in 2D and 3D cell culture.

History

Topic

  • Drug delivery systems
  • Organic Polymers

Email Address of Submitting Author

robert.luxenhofer@uni-wuerzburg.de

Institution

Julius-Maximilians-University Würzburg

Country

Germany

ORCID For Submitting Author

0000-0001-5567-7404

Declaration of Conflict of Interest

No conflict declared

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