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DENV and SARS revised 15.07.2020.pdf (1.1 MB)

Drug Repurposing Commonly Against Dengue Virus Capsid and SARS-CoV-2 Nucleocapsid: An in Silico Approach

preprint
revised on 14.07.2020, 18:36 and posted on 15.07.2020, 05:59 by Debica Mukherjee, Rupesh Roy, UPASANA RAY

In the middle of SARS-CoV-2 pandemic, dengue virus (DENV) is giving a silent warning as the season approaches nearer. There is no specific antiviral against DENV for use in the clinics. Thus, considering these facts we can potentially face both these viruses together increasing the clinical burden. The search for anti-viral drugs against SARS-CoV-2 is in full swing and repurposing of already ‘in-use’ drugs against other diseases or COVID-19 has drawn significant attention. Earlier we had reported few FDA approved anti-viral and anti-microbial drugs that could be tested for binding with SARS-CoV-2 nucleocapsid N terminal domain. We explored the possibility of interactions of the drugs screened for SARS-CoV2 with Dengue virus capsid protein. We report five FDA approved drugs that were seen to be docking onto the SARS-CoV-2 nucleocapsid RNA binding domain, also docking well with DENV capsid protein on the RNA binding site and/or the capsid’s membrane fusion domain. Thus, the present study proposes these five drugs as common antiviral candidates against both SARS-CoV-2 and DENV although the in silico study is subject to further validations.


History

Email Address of Submitting Author

ray.upasana@gmail.com

Institution

CSIR-Indian Institute of Chemical

Country

India

ORCID For Submitting Author

0000-0003-4783-9295

Declaration of Conflict of Interest

There is no conflict of interest

Version Notes

This is a revised version of the paper.

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