ChemRxiv
These are preliminary reports that have not been peer-reviewed. They should not be regarded as conclusive, guide clinical practice/health-related behavior, or be reported in news media as established information. For more information, please see our FAQs.
BES_MIL100Modulator_07Aug20-ChemRxiv.pdf (2.03 MB)
0/0

Drug Guest Molecules as Modulators During One-Step Mechanochemical Encapsulation in MIL-100 (Fe) Framework

preprint
submitted on 09.08.2020 and posted on 10.08.2020 by Barbara Souza, Annika Moslein, Kirill Titov, James D. Taylor, Svemir Rudic, Jin-Chong Tan

We propose a facile one-pot mechanochemical strategy for the encapsulation of drug guest molecules (e.g. 5‑fluorouracil, caffeine, and aspirin) in MIL-100 (Fe) as the porous host framework. We reveal the modulating effect of 5-FU and caffeine, giving highly crystalline MIL‑100 (Fe), whereas aspirin led to the formation of an amorphous MOF phase. Inelastic neutron scattering (INS) was used to probe the intermolecular interactions underpinning the drug@MIL‑100 assemblies, where strong guest-host interaction was achieved via this eco-friendly approach.

Funding

Minas Gerais Research Foundation (FAPEMIG CNPJ n21.949.888/0001-83)

Engineering and Physical Sciences Research Council (EPSRC) Grant No. EP/ N014960/1

European Research Council (ERC) Consolidator Grant under Grant Agreement 771575 (PROMOFS)

History

Email Address of Submitting Author

jin-chong.tan@eng.ox.ac.uk

Institution

University of Oxford

Country

United Kingdom

ORCID For Submitting Author

orcid.org/0000-0002-5770-408X

Declaration of Conflict of Interest

No conflict of interests

Exports