ChemRxiv
These are preliminary reports that have not been peer-reviewed. They should not be regarded as conclusive, guide clinical practice/health-related behavior, or be reported in news media as established information. For more information, please see our FAQs.
bioxriv GAOXY revised 4 gong.docx (2.03 MB)

Double Lock the COVID 19: Inhibit SARS COV 2 Replication and Suppress Inflammation Cytokine Level by the Golden Compounds

preprint
submitted on 25.06.2020 and posted on 29.06.2020 by Zhesheng He, Chunyu Zhang, Zhongying Du, Wencong Zhao, Wenchao Niu, Yucong Gao, Yuhui Dong, Jiadong Fan, Bo he, Peng Cao, Huaidong Jiang, Gong Yong, Xueyun Gao
Our studies implied the golden compounds may be more effective against COVID 19 as they synergy inhibit SARS COV 2 replication and down regulation inflammation cytokine level. Our crystal structure studies firstly revealed Au (I) ions, derived from auranofin (AF) or gold cluster (GA), covalently bind sulfur atom of Cys145 and Cys156 of Mpro of SARS COV 2. The auranofin or gold cluster well inhibit Mpro activity in vitro. Auranofin or gold cluster could well suppress inflammation cytokine level of IL 6, IL 1β, TNF α via down regulation NF κB activation in macrophage. The cell viability and rat toxicity studies show gold cluster is more safety when compared FDA approved auranofin. The rat pharmacokinetic studies of gold cluster revealed its good bioavailability.

History

Email Address of Submitting Author

gaoxy@ihep.ac.cn

Institution

Beijing University of Technology

Country

P. R. China

ORCID For Submitting Author

0000-0002-2267-9945

Declaration of Conflict of Interest

no conflict interest

Exports

Logo branding

Keyword(s)

Exports