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Double Ligand-Enabled Ni-Catalyzed C-H Alkenylation of Amines with Alkynes

preprint
submitted on 01.12.2020, 23:57 and posted on 03.12.2020, 07:20 by Wei-Wei Yao, Ran Li, Hao Chen, Ming-Kai Chen, Yu-Xin Luan, Yi Wang, Zhi-Xiang Yu, mengchun ye
A nickel-catalyzed C−H alkenylation of amines with alkynes was developed, providing a series of allylic amines in up to 94% yield. The use of bulky amino protecting group (triisopropylphenylsulfonyl) and double ligands (IPr and PCy3) proved critical to the reaction efficiency.

Funding

the National Natural Science Foundation of China (21672107, 21871145, 21933003, and 91856104)

the Fundamental Research Funds for the Central Universities (63191601)

History

Email Address of Submitting Author

mcye@nankai.edu.cn

Institution

Nankai University

Country

China

ORCID For Submitting Author

0000-0002-2019-5365

Declaration of Conflict of Interest

The authors declare no competing financial interests.

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