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Double Ligand-Enabled Ni-Catalyzed C-H Alkenylation of Amines with Alkynes
preprintsubmitted on 01.12.2020, 23:57 and posted on 03.12.2020, 07:20 by Wei-Wei Yao, Ran Li, Hao Chen, Ming-Kai Chen, Yu-Xin Luan, Yi Wang, Zhi-Xiang Yu, mengchun ye
A nickel-catalyzed C−H alkenylation of amines with alkynes was developed, providing a series of allylic amines in up to 94% yield. The use of bulky amino protecting group (triisopropylphenylsulfonyl) and double ligands (IPr and PCy3) proved critical to the reaction efficiency.