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DoE-Paper-chemrxiv-v1.pdf (20.48 MB)

DoE-It-Yourself: A Case Study for Implementing Design of Experiments into Nanoparticle Synthesis

submitted on 29.05.2019 and posted on 30.05.2019 by Niamh Mac Fhionnlaoich, Ye Yang, Runzhang Qi, Federico Galvanin, Stefan Guldin
Predictable and repeatable outcome is a major issue in nanoparticle synthesis. Traditionally, chemists rely on the one-factor-at-a-time method to investigate and optimise synthetic processes; however, this method is inefficient and often misleading. Design of Experiments (DoE), in contrast, can provide a greater amount of information in fewer experiments and lends itself to producing more reproducible results. Nevertheless, DoE techniques are only used by a relatively low number of practitioners in nanoparticle research. Here, we provide a case study on the synthesis of oleylamine-capped gold nanoparticles (AuNPs). Through the use of DoE, we achieved a marked reduction in dispersity and developed a model to carefully control the mean diameter of the nanoparticle populations.


EPSRC (EP/M507970/1)

EU H2020 (633635; DIACHEMO)


Email Address of Submitting Author


University College London


United Kingdom

ORCID For Submitting Author


Declaration of Conflict of Interest

No conflict of interest to declare