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DoE-Paper-chemrxiv-v1.pdf (20.48 MB)

DoE-It-Yourself: A Case Study for Implementing Design of Experiments into Nanoparticle Synthesis

submitted on 29.05.2019, 13:49 and posted on 30.05.2019, 16:00 by Niamh Mac Fhionnlaoich, Ye Yang, Runzhang Qi, Federico Galvanin, Stefan Guldin
Predictable and repeatable outcome is a major issue in nanoparticle synthesis. Traditionally, chemists rely on the one-factor-at-a-time method to investigate and optimise synthetic processes; however, this method is inefficient and often misleading. Design of Experiments (DoE), in contrast, can provide a greater amount of information in fewer experiments and lends itself to producing more reproducible results. Nevertheless, DoE techniques are only used by a relatively low number of practitioners in nanoparticle research. Here, we provide a case study on the synthesis of oleylamine-capped gold nanoparticles (AuNPs). Through the use of DoE, we achieved a marked reduction in dispersity and developed a model to carefully control the mean diameter of the nanoparticle populations.


EPSRC (EP/M507970/1)

EU H2020 (633635; DIACHEMO)


Email Address of Submitting Author


University College London


United Kingdom

ORCID For Submitting Author


Declaration of Conflict of Interest

No conflict of interest to declare