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Diverse Cyclopentenes via Enantioselective Cu-Catalyzed Desymmetrization

preprint
submitted on 02.08.2018 and posted on 02.08.2018 by Reece Jacques, Robert D. C. Pullin, Stephen P. Fletcher

A highly regio-, diastereo- and enantioselective Cu-catalyzed desymmetrization of diverse meso-bisphosphates with alkyl zirconium nucleophiles has been developed. The reaction allows access to a broad range of functionalized cyclopentenes with up to three contiguous stereogenic centers, including quaternary centers and spirocyclic ring systems.

History

Email Address of Submitting Author

reece.jacques@chem.ox.ac.uk

Institution

University of Oxford

Country

United Kingdom

ORCID For Submitting Author

0000-0002-1953-8527

Declaration of Conflict of Interest

No conflict of interest

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