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Divergent Total Syntheses of Enmein-Type Natural Products: (–)-Enmein, (–)-Isodocarpin and (–)-Sculponin R

preprint
submitted on 03.04.2018 and posted on 04.04.2018 by Guangbin Dong, Saiyong Pan, Sicong Chen
Divergent total syntheses of enmein-type natural products, (–)-enmein, (–)-isodocarpin and (–)-sculponin R, have been achieved in a concise fashion. Key features of the strategy include (a) an efficient early-stage cage formation to control succeeding diastereoselectivity, (b) an one-pot acylation/akylation/lactonization to construct the C-ring and C8 quarternary center, (c) a reductive alkenylation approach to construct enmain D/E rings and (d) a flexible route to allow divergent syntheses of three natural products.

History

Email Address of Submitting Author

gbdong@uchicago.edu

Institution

University of Chicago

Country

United States

ORCID For Submitting Author

0000-0003-1331-6015

Declaration of Conflict of Interest

no conflict of interest

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