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ManuscriptSI Elek et al..pdf (7.39 MB)

Divergent Access to Histone Deacetylase Inhibitory Cyclopeptides via Late- Stage Cyclopropane Ring Cleavage Strategy. Short Synthesis of Chlamydocin

submitted on 11.07.2019, 08:55 and posted on 11.07.2019, 13:51 by Gabor Zoltan Elek, Kaur Koppel, Dzmitry Zubrytski, Nele Konrad, Ivar Järving, Margus Lopp, Dzmitry Kananovich
We present a unified step-economical strategy to access histone deacetylase inhibitory peptides, based on late-stage installation of zinc-binding functionalities via the cleavage of the strained cyclopropane ring in the common pluripotent cyclopropanol precursor. The efficacy of the proposed diversity-oriented approch has been validated by short stereoselective synthesis of a natural product chlamydocin and a number of its analogs.


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Tallinn University of Technology



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Declaration of Conflict of Interest

no conflict to declare