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Divergent Access to Histone Deacetylase Inhibitory Cyclopeptides via Late- Stage Cyclopropane Ring Cleavage Strategy. Short Synthesis of Chlamydocin

preprint
submitted on 11.07.2019 and posted on 11.07.2019 by Gabor Zoltan Elek, Kaur Koppel, Dzmitry Zubrytski, Nele Konrad, Ivar Järving, Margus Lopp, Dzmitry Kananovich
We present a unified step-economical strategy to access histone deacetylase inhibitory peptides, based on late-stage installation of zinc-binding functionalities via the cleavage of the strained cyclopropane ring in the common pluripotent cyclopropanol precursor. The efficacy of the proposed diversity-oriented approch has been validated by short stereoselective synthesis of a natural product chlamydocin and a number of its analogs.

History

Email Address of Submitting Author

dzmitry.kananovich@taltech.ee

Institution

Tallinn University of Technology

Country

Estonia

ORCID For Submitting Author

0000-0002-2664-4491

Declaration of Conflict of Interest

no conflict to declare

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