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tatiomycin_crx_submission.pdf (414.74 kB)

Discovery of the Antibiotic Polyketide Tatiomicin via a Genomics Guided Analysis of Amycolatopsis sp. DEM30355

preprint
submitted on 10.12.2020, 16:34 and posted on 14.12.2020, 05:05 by Bernhard Kepplinger, Joseph Cowell, Stephanie Morton-Laing, Corinne Wills, Emma Marrs, John Perry, Joe Grey, Michael Goodfellow, Jeff Errington, Michael Probert, Bill Clegg, Jonathan Bogaerts, Wouter Herrebout, Nick E. E. Allenby, Michael Hall
The application of genomic techniques to the investigation of understudied species of actinobacteria provides an expedited route to the discovery of new bioactive natural products. We report the isolation of the antibiotic polyketide tatiomicin, through a genomics and bioactivity informed analysis of the metabolome of the extremophile Amycolatopsis sp. DEM30355. Structural elucidation including absolute stereochemical assignment was performed using complementary crystallographic, spectroscopic and computational methods. Tatiomicin shows antibiotic activity against Gram-positive bacteria, including Methicillin-resistant Staphylococcus aureus (MRSA).

Funding

Industrial Doctorate Centre: Biopharmaceutical Process Development

Engineering and Physical Sciences Research Council

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The Development and Commercialisation of Novel Antibiotic Compounds

Innovate UK

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Natural Product Antibiotics for multi-drug resistant pathogens

Innovate UK

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History

Email Address of Submitting Author

michael.hall@newcastle.ac.uk

Institution

Newcastle University

Country

United Kingdom

ORCID For Submitting Author

0000-0001-6475-9161

Declaration of Conflict of Interest

NEEA/Demuris have filed a patent on tatiomicin

Version Notes

version 1.0

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