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Direct Access to Mono-Protected Homoallylic 1,2-Diols via Dual Chromium/ Photoredox Catalysis

preprint
revised on 20.07.2020 and posted on 21.07.2020 by Felix Schäfers, Linda Quach, J. Luca Schwarz, Mar Saladrigas, Constantin G. Daniliuc, Frank Glorius

A dual catalytic strategy enables the efficient synthesis of mono-protected homoallylic 1,2-diols by coupling abundant aldehydes with simple (silyl) enol ethers, thus providing direct access to this important motif without the (super)stoichiometric use of prefunctionalized metal-allyl species. A variety of silyl- and alkyl-based protecting groups is shown and functional group tolerance, chemoselectivity and scalability are highlighted.

Funding

Deutsche Forschungsgemeinschaft (Leibniz Award)

History

Email Address of Submitting Author

glorius@uni-muenster.de

Institution

Westfälische Wilhelms-Universität Münster

Country

Deutschland

ORCID For Submitting Author

0000-0002-0648-956X

Declaration of Conflict of Interest

No conflict of interest

Exports