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Diffusion Enhanced Amide Bond Formation on Solid Support
preprintsubmitted on 01.09.2019, 05:38 and posted on 04.09.2019, 16:30 by Johnny N Naoum, Israel Alshanski, Agata Gitlin-Domagalska, Moshe Bentolila, Chaim Gilon, Mattan Hurevich
Performing amino acids coupling reactions on solid support using fast overhead stirring is far more efficient than the common shaking mixing methods. Stirring does not harm the polystyrene beads and allows to decrease dramatically the amount of reagents used and wasted in these transformations.