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Differences in the Performance of Allyl Based Palladium Precatalysts for Suzuki-Miyaura Reactions

preprint
submitted on 26.06.2020 and posted on 29.06.2020 by Matthew R. Espinosa, Angelino Doppiu, Nilay Hazari
We evaluate the activity of different allyl-based precatalysts in Suzuki-Miyaura reactions as the ancillary ligand (NHC or phosphine), reaction conditions, and substrates are varied. In some cases, we connect relative activity to both the mechanism of activation and the prevalence of the formation of inactive palladium(I) dimers.

Funding

NIHGMS R01GM120162

History

Email Address of Submitting Author

nilay.hazari@yale.edu

Institution

Yale University

Country

United States of America

ORCID For Submitting Author

0000-0001-8337-198X

Declaration of Conflict of Interest

This work was primarily funded by Umicore, who own the rights to all of the allyl-based precatalysts studied in this work. Additionally, NH is an inventor on patents relating to the Yale precatalyst.

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