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Diastereoselective Synthesis of Spiro and Chlorocyclopropanes from Camphorpyrazolidinone derived -Unsaturated Amides

preprint
submitted on 06.12.2020, 20:52 and posted on 08.12.2020, 04:55 by Sudershan Reddy Gondi

High diastereoselectivity are observed in the addition of gem-dichlorocarbene to an optically pure a,b-unsaturated amides derived from a chiral camphorpyrazolidinone. A novel route to the asymmetric synthesis of spiro [2,2]-pentane carboxylic acid esters derivatives through gem-dichlorocyclopropane is described.

Funding

G.S.R thankful to National Science Council of Taiwan, (ROC) for financial support in the form of Post-Doctoral Fellowship during February 2000-July 2003. G.S.R is thankful to Kwunmin Chen at National Taiwan Normal University, Taipei, Taiwan, for conducting the experiments and collection and processing of the spectral data and X-ray data are gratefully acknowledged.

History

Email Address of Submitting Author

gondisr@gmail.com

Institution

National Taiwan Normal University

Country

Taiwan

ORCID For Submitting Author

0000-0002-1363-2352

Declaration of Conflict of Interest

There is no Competing Interests pending

Licence

Exports