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Diastereoselective Cyclopropanation by Using Camphorpyrazolidinone Derived α,β-Unsaturated Amides and Ylide

preprint
submitted on 28.11.2020, 18:10 and posted on 01.12.2020, 06:45 by Sudershan Reddy Gondi

Abstract: High to moderate diastereoselectivity and high chemical yield are observed in the Michael addition of ylide and chiral camphorpyrazolidinone ylide to an optically pure a,b-unsaturated carboxylic acid derivatives derived from a chiral camphorpyrazolidinone and a,b-unsaturated carbonyl respectively. A novel route to the asymmetric synthesis of cyclopropanation derivatives is described.

Funding

G.S.R thankful to National Science Council of Taiwan, (ROC) for financial support in the form of Post-Doctoral Fellowship during February 2000-July 2003. G.S.R is thankful to Kwunmin Chen at National Taiwan Normal University, Taipei, Taiwan, for conducting the experiments and collection and processing of the spectral data and X-ray data are gratefully acknowledged.

History

Email Address of Submitting Author

gondisr@gmail.com

Institution

National Taiwan Normal University

Country

Taiwan

ORCID For Submitting Author

https://orcid.org/0000-0002-1363-2352

Declaration of Conflict of Interest

There is no Competing Interests pending

Licence

Exports