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Development of an Amino Sugar-Based Supramolecular Hydrogelator with Reduction Responsiveness

preprint
submitted on 03.03.2021, 11:00 and posted on 04.03.2021, 05:11 by Sayuri L. Higashi, Masato Ikeda
Stimuli-responsive supramolecular hydrogels are a newly emerging class of aqueous soft materials with a wide variety of bioapplications. Here we report a reduction-responsive supramolecular hydrogel constructed from a markedly simple low-molecular-weight hydrogelator, which is developed on the basis of modular molecular design containing a hydrophilic amino sugar and a reduction-responsive nitrophenyl group. The hydrogel formation ability differs significantly between glucosamine- and galactosamine-based self-assembling molecules, which are epimers at the C4 position, and only the glucosamine-based derivative can act as a hydrogelator.

Funding

KOSÉ Cosmetology Research Foundation

JSPS Research Fellowship for Young Scientists

History

Email Address of Submitting Author

m_ikeda@gifu-u.ac.jp

Institution

Gifu University

Country

Japan

ORCID For Submitting Author

0000-0003-4097-8292

Declaration of Conflict of Interest

The authors declare no competing financial interests

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