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Final draft SAICAR and oral cancer final 30012021.pdf (624.95 kB)

Detection of Nail Oncometabolite SAICAR in Oral Cancer and Its Molecular Interactions with PKM2 Enzyme

preprint
submitted on 30.01.2021, 10:43 and posted on 02.02.2021, 10:21 by Rushikesh Patel, Ajay Kumar, Kiran Bharat Lokhande, K. Venkateswara Swamy, Prof. Sachin C Sarode, Prof. Nilesh Kumar Sharma

Oncometabolites are known to drive metabolic adaptations in oral cancer. These oncometabolites serve as biomarkers for early detection of oral cancer. Among potential oncometabolite, SAICAR is one of them that support growth and invasiveness of cancer cells. SAICAR has been reported to activate Pyruvate Kinase M2 (PKM2) enzyme, which in turn favors the survival of cancer cells in low glucose tumor microenvironment. There is a significant gap in detection of SAICAR in biological fluids/materials including nails of oral cancer patients.

History

Email Address of Submitting Author

nilesh.sharma@dpu.edu.in

Institution

Dr. D.Y. Patil Vidyapeeth, Pune, Maharashtra, India, 411033.

Country

India

ORCID For Submitting Author

0000-0002-8774-3020

Declaration of Conflict of Interest

None

Version Notes

Preprint draft