Designing of Cytotoxic and Helper T Cell Epitope Map Provides Insights into the Highly Contagious Nature of the Pandemic Novel Coronavirus SARS-CoV2

11 May 2020, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

This study provides key insights into the contagious nature of SARS-CoV2 through analyses of T cell epitopes designed from SARS-CoV2 proteome. All top-scoring cytotoxic T cell epitopes from ORF1ab and helper T cell epitopes identified from all proteins were utilized to provide crucial insights into its pathogenesis. These T cell epitopes can be used as prophylactic or therapeutic multi-subunit vaccine or as diagnostic tools.

Keywords

SARS CoV2
T cell epitope content
immuno regulation
immunoinformatics approach
Immune Epitope Database

Supplementary materials

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muscleEnvelope
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muscleMembrane
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muscleNS3
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muscleNS6
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muscleNucleocapsid
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muscleORF1ab
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muscleORF7a
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muscleORF8
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muscleSpike
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S4 Supplementary material PickPocket
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S5 Supplementary material NetCTLpan results
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S6 Supplementary material NetMHCIIpan results
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Supplementary Figure S10
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Supplementary table S1
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Supplementary table S2
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Supplementary table S3
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