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Design of a Multi-Use Photoreactor to Enable Visible Light Photocatalytic Chemical Transformations and Labeling in Live Cells

preprint
submitted on 24.06.2020 and posted on 26.06.2020 by Noah Bissonnette, Keun Ah Ryu, Tamara Reyes-Robles, Sharon Wilhelm, Erik Hett, Lee Roberts, Daria Hazuda, Jared Willis, Rob Oslund, Niyi Fadeyi

Despite the growing utilization of visible light photochemistry in both chemistry and biology, a general low-heat photoreactor for use across these different disciplines does not exist. Herein, we describe the design and utilization of a standardized photoreactor for visible light driven activation and photocatalytic chemical transformations. Using this single benchtop photoreactor, we perform photoredox reactions across multiple visible light wavelengths, a high throughput photocatalytic cross coupling reaction, and in vitro labeling of proteins and live cells. Given the success of this reactor in all tested applications, we envision that this multi-use photoreactor will be widely used in biology, chemical biology, and medicinal chemistry settings.

History

Email Address of Submitting Author

rob.oslund@merck.com

Institution

Exploratory Science Center, Merck & Co., Inc.

Country

United States

ORCID For Submitting Author

0000-0002-2920-9532

Declaration of Conflict of Interest

N.B.B., K.A.R., T.R.R., S. W., E.C.H., L.R.R., D.J.H., R.C.O., O.O.F. are employees of Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., Kenilworth, NJ, USA. M.J.W. is an employee of Efficiency Aggregators. A patent on the photoreactor has been filed by Efficiency Aggregators.

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