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submitted on 15.01.2020 and posted on 17.01.2020by DYLAN SMITH, Yuki Hosono, Masahiro Nagata, Sho Yamasaki, Spencer Williams
The innate immune receptor Mincle senses lipid-based molecules derived from pathogens, commensals and altered self. Based on emerging structure-activity relationships we design simple alkyl 6-O-acyl-b-D-glucosides that are effective agonists of Mincle and signal with potency on par with the prototypical ligand trehalose dimycolate.