These are preliminary reports that have not been peer-reviewed. They should not be regarded as conclusive, guide clinical practice/health-related behavior, or be reported in news media as established information. For more information, please see our FAQs.
Design of Potent Mincle Signalling Agonists Based on an Alkyl b- Glucoside Template
preprintsubmitted on 15.01.2020, 11:33 and posted on 17.01.2020, 23:08 by DYLAN SMITH, Yuki Hosono, Masahiro Nagata, Sho Yamasaki, Spencer Williams
The innate immune receptor Mincle senses lipid-based molecules derived from pathogens, commensals and altered self. Based on emerging structure-activity relationships we design simple alkyl 6-O-acyl-b-D-glucosides that are effective agonists of Mincle and signal with potency on par with the prototypical ligand trehalose dimycolate.
Read the published paper
in Chemical Communications
Unravelling the immunology of complex glycolipids by chemical synthesis
Australian Research CouncilFind out more...