ChemRxiv
These are preliminary reports that have not been peer-reviewed. They should not be regarded as conclusive, guide clinical practice/health-related behavior, or be reported in news media as established information. For more information, please see our FAQs.
1/1
3 files
0/0

Design of Potent Mincle Signalling Agonists Based on an Alkyl b- Glucoside Template

preprint
submitted on 15.01.2020 and posted on 17.01.2020 by DYLAN SMITH, Yuki Hosono, Masahiro Nagata, Sho Yamasaki, Spencer Williams
The innate immune receptor Mincle senses lipid-based molecules derived from pathogens, commensals and altered self. Based on emerging structure-activity relationships we design simple alkyl 6-O-acyl-b-D-glucosides that are effective agonists of Mincle and signal with potency on par with the prototypical ligand trehalose dimycolate.

Funding

Unravelling the immunology of complex glycolipids by chemical synthesis

Australian Research Council

Find out more...

Japan Agency for Medical Research and Development (AMED)

History

Email Address of Submitting Author

sjwill@unimelb.edu.au

Institution

University of Melbourne

Country

Australia

ORCID For Submitting Author

0000-0001-6341-4364

Declaration of Conflict of Interest

no conflict of interest

Exports

Logo branding

Exports