Design of Potent Mincle Signalling Agonists Based on an Alkyl b- Glucoside Template

17 January 2020, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

The innate immune receptor Mincle senses lipid-based molecules derived from pathogens, commensals and altered self. Based on emerging structure-activity relationships we design simple alkyl 6-O-acyl-b-D-glucosides that are effective agonists of Mincle and signal with potency on par with the prototypical ligand trehalose dimycolate.

Keywords

innate immunity
adjuvant
glycolipid
lectin receptor
Mincle
glycoimmunology

Supplementary materials

Title
Description
Actions
Title
draft 150120
Description
Actions
Title
supp info
Description
Actions

Comments

Comments are not moderated before they are posted, but they can be removed by the site moderators if they are found to be in contravention of our Commenting Policy [opens in a new tab] - please read this policy before you post. Comments should be used for scholarly discussion of the content in question. You can find more information about how to use the commenting feature here [opens in a new tab] .
This site is protected by reCAPTCHA and the Google Privacy Policy [opens in a new tab] and Terms of Service [opens in a new tab] apply.