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Design and Synthesis of Novel Peptidomimetics for Cancer Immunotherapy

preprint
submitted on 10.09.2020 and posted on 10.09.2020 by Ceyda Köse, Esra Uysal, Büşra Yazıcı, Zeynep Tuğay, Serap İpek Dingiş Birgül, Hamdullah Yanık, Ece Tavukcuoglu, Sevgi Gulyuz, Atilla Akdemir, Güneş Esendağlı, Özgür Yılmaz, Onur Alptürk
Tumor cells benefit from some certain signals, which are referred to as “immune checkpoints”, to escape immune-mediated destruction. With that in mind, it is believed that the blockade of these points, such as programmed cell death Ligand-1 (PD-L1) and programmed cell death 1 (PD-1), can restore an adaptative immune response against tumoral cells. In this study, we have designed and synthesized some novel peptidomimetics with a 2-aminobenzathiazole scaffold, which targets the PD-1/PDL-1 pathway. In the viability assay, it was found that these compounds decreased the proliferation of peripheral blood mononuclear cells in the concentration of 10 uM. Overall, our results indicate that these novel compounds are potential checkpoint inhibitors for cancer immunotherapy.

Funding

Turkish Scientific and Technological Council (project numbers: TUBITAK-116E661)

Turkish Scientific and Technological Council (project numbers: TUBITAK-116E662)

Turkish Scientific and Technological Council (project numbers: TUBITAK-116E644)

History

Email Address of Submitting Author

onur.alpturk@itu.edu.tr

Institution

Istanbul Technical University

Country

Turkey

ORCID For Submitting Author

0000-0001-6618-4111

Declaration of Conflict of Interest

no conflict of interest

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