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Design_and_synthesis_of_9-dialkylamino-6-[(1H-1,2,3-triazol-4-yl)methoxy]-9H-purines_Lorente-Macias_et_al.pdf (834.8 kB)

Design and Synthesis of 9-Dialkylamino-6-[(1H-1,2,3-triazol-4-yl)methoxy]-9H-purines

submitted on 29.01.2021, 15:41 and posted on 01.02.2021, 07:09 by Álvaro Lorente-Macías, Juan J. Díaz-Mochón, María José Pineda de las Infantas y Villatoro, Asier Unciti-Broceta

The purine ring is a common structural component of a large variety of biomolecules with important roles in both physiological and pathological processes. The biological ubiquity and versatility of this heterocyclic scaffold makes it a privileged structure in drug design. Consequently, the development of novel purine analogs remains of great interest in the medicinal chemistry field. Here, we report the design and synthesis of a series of 9-dialkylamino-6-[(1H-1,2,3-triazol-4 yl)methoxy]-9H-purines and their intermediates. This series of compounds aims to diversify the chemical space around the purine scaffold in the search towards the discovery of new biologically active small molecules.


FPU grant ref. 14/00818

Edinburgh Cancer Research Centre


Email Address of Submitting Author


University of Edinburgh


United Kingdom

ORCID For Submitting Author


Declaration of Conflict of Interest

The authors declare no competing financial interest.