Defluorosilylation of Trifluoromethane: Upgrading an Environmentally Damaging Fluorocarbon
The rapid, room-temperature defluorosilylation of trifluoromethane, a highly potent greenhouse gas, has been achieved using a simple silyl lithium reagent. An extensive computational mechanistic analysis provides a viable reaction pathway and demonstrates the unexpected electrophilic nature of LiCF3. The reaction generates a bench stable fluorinated building block that shows promise as an easy-to-use difluoromethylating agent. The difluoromethyl group is an increasingly important bioisostere in active pharmaceutical ingredients, and therefore our methodology creates value from waste. The potential scalability of the process has been demonstrated by achieving the reaction on a gram-scale.
ERC StG FluoroFix 677367
Email Address of Submitting Authorm.firstname.lastname@example.org
InstitutionImperial College London
ORCID For Submitting Author0000-0002-9339-9182
Declaration of Conflict of InterestThere are no conflicts to declare.
Version NotesVersion 1.1
Read the published paper
in Chemical Communications