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Decoding the Proteome of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) for Cell-Penetrating Peptides Involved in Pathogenesis or Applicable as Drug Delivery Vectors

preprint
submitted on 31.05.2020 and posted on 02.06.2020 by Shiva Hemmati, Yasaman Behzadipour, Mahdi Haddad
Synthetic or natural-derived cell penetrating peptides (CPPs) are vastly investigated as tools for the intracellular delivery of membrane-impermeable molecules. As viruses are obligate intracellular parasites, viral originated CPPs have been considered as suitable shuttling vectors for cargo transportation. A total of 310 CPPs were identified in the proteome of SARS-CoV-2. SCV2-CPPs span the regions involved in replication, protein-nucleotide and protein-protein interaction, protein-metal ion interaction, and stabilization of homo/hetero-oligomers. Computational analyses showed that the most optimal SCV2-CPP candidates as vectors for drug delivery are SCV2-CPP118, SCV2-CPP119, SCV2-CPP122, and SCV2-CPP129 of NSP12. Conclusively, the workflow of this study provides a platform for profound screening of viral proteomes as a rich source of bio-therapeutics or drug delivery carriers.

History

Email Address of Submitting Author

hemmatish@sums.ac.ir

Institution

Shiraz University of Medical Sciences

Country

Iran

ORCID For Submitting Author

0000-0001-9071-9569

Declaration of Conflict of Interest

No conflict of interest.

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