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DNA/TNA Mesoscopic Modeling of Melting Temperatures Suggest Weaker Hydrogen Bonding of CG than in DNA/RNA

submitted on 03.03.2020, 22:39 and posted on 04.03.2020, 12:55 by Maria Izabel Muniz, Hershel Lackey, Jennifer Heemstra, Gerald Weber
TNA/DNA hybrids share several similarities to RNA/DNA, such as the tendency to form A-type helices and a strong dependency of their thermodynamic properties on purine/pyrimidine ratio. However, unlike RNA/DNA, not much is known about the base-pair properties of TNA. Here, we use a mesoscopic analysis of measured melting temperatures to obtain an estimate of hydrogen bonds and stacking interactions. Our results reveal that the AT base pairs in TNA/DNA have nearly identical hydrogen bond strengths than their counterparts in RNA/DNA, but surprisingly CG turned out to be much weaker despite similar stability.


Conselho Nacional de Desenvolvimento Científico e Tecnológico

Fundação de Amparo à Pesquisa do Estado de Minas Gerais

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

National Science Foundation CHE-1904885

Air Force Institute of Technology Civilian Institute Program


Email Address of Submitting Author


Universidade Federal de Minas Gerais



ORCID For Submitting Author


Declaration of Conflict of Interest

no conflict of interest