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DFT-Assisted Design and Evaluation of Bifunctional Amine/Pyridine- Oxazoline Metal Catalysts for Additions of Ketones to Unactivated Alkenes and Alkynes

preprint
submitted on 08.06.2018 and posted on 08.06.2018 by Eric Greve, Jacob D. Porter, Chris Dockendorff
Bifunctional catalyst systems for the direct addition of ketones to unactivated alkenes/alkynes were designed and modeled by density functional theory (DFT). The designed catalysts possess bidentate ligands suitable for binding of pi-acidic group 10 metals capable of activating alkenes/alkynes, and a tethered organocatalyst amine to activate the ketone via formation of a nucleophilic enamine intermediate. The structures of the designed catalysts before and after C–C bond formation were optimized using DFT, and reaction steps involving group 10 metals were predicted to be significantly exergonic. A novel oxazoline precatalyst with a tethered amine separated by a meta-substituted benzene spacer was predicted to have the potential to promote the desired reactions without undergoing self-quenching. The first example of a precatalyst of this class was synthesized via a 10-step sequence that includes a key regioselective epoxide ring-opening step. It was combined with group 10 metal salts, including cationic Pd(II) and Pt(II), and screened for the direct addition of ketones to several alkenes or an internal alkyne. 1H NMR studies suggest that catalyst-catalyst interactions with this system via amine–metal coordination may preclude the desired addition reactions. The catalyst design approach disclosed here, and the promising calculations obtained with square planar group 10 metals, light a path for the discovery of novel bifunctional catalysts for C–C bond formation.

Funding

ACS PRF 55732-DNI1

History

Email Address of Submitting Author

christopher.dockendorff@mu.edu

Institution

Marquette University

Country

United States

ORCID For Submitting Author

0000-0002-4092-5636

Declaration of Conflict of Interest

None

Exports