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Cytotoxicity of Mn-Based photoCORMs of Ethynyl-α-Diimine Ligands Against Different Cancer Cell Lines: The Key Role of CO-Depleted Metal Fragments

preprint
submitted on 26.03.2020 and posted on 30.03.2020 by Jeremie Rossier, Joachim Delasoie, Laetitia Haeni, Daniel Hauser, Barbara Rothen-Rutishauser, Fabio Zobi
A series of fac-[Mn(CO)3]+ complexes bearing 4-ethynyl-2,2'-bipyridine and 5-ethynyl-1,10-phenanthroline α-diimine ligands were synthetized, characterized and conjugated to vitamin B12, previously used as a vector for drug delivery, to take advantage of its water solubility and specificity toward cancer cells. The compounds act as photoactivatable carbon monoxide-releasing molecules (photoCORMs) rapidly liberating on average ca. 2.3 equivalents of CO upon photo-irradiation. Complexes and conjugates were tested for their anticancer effects, both in the dark and following photo-activation, against breast cancer MCF-7, lung carcinoma A549 and colon adenocarcinoma HT29 cell lines as well as immortalized human bronchial epithelial cells 16HBE14o- as the non-carcinogenic control. Our results indicate that the light-induced cytotoxicity these photoCORMs can be attributed to both their released CO and to their CO-depleted metal fragments (i-photoCORMs) including liberated ligands.

Funding

Swiss National Science Foundation PP00P2_170589

History

Email Address of Submitting Author

fabio.zobi@unifr.ch

Institution

University of Fribourg

Country

Switzerland

ORCID For Submitting Author

0000-0002-9077-7184

Declaration of Conflict of Interest

No Conflict of Interest

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