Correlation Between Yield and Reduced Mass of Raw Materials in Coupling Reactions
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Product yields in various organic reactions such as C-N, C-C, and C-O coupling reactions were found to be correlated with reduced mass of raw materials. The product yields decreased gradually with increasing the reduced mass according to a regression equation, yield = − 0.2047(MAB/n) + 104.2, where MAB is the reduced mass per mole and n is the number of reaction sites.