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Copper(II) and Zinc(II) Complexes of Mono- and Bis-1,2,3-Triazolesubstituted Heterocyclic Ligands

preprint
submitted on 13.04.2020 and posted on 17.04.2020 by Natalija Pantalon Juraj, Marko Krklec, Tiana Novosel, Berislav Perić, Robert Vianello, Silvana Raić-Malić, Srećko Kirin
Chelating 1,4-disubstituted mono- (8a−8d) and bis-1,2,3-triazole-based (9a−11a) ligands were prepared by regioselective copper(I)-catalysed 1,3-dipolar cycloaddition of terminal alkynes with aromatic azides, together with bioconjugate 13a synthesized by amide coupling of L-phenylalanine methyl ester to 11a. Cu(II) and Zn(II) complexes were prepared and single crystal structures were determined for complexes 8aCu, 8dCu, 9cCu and 10cCu, as well as the free ligands 10a and 10c. The in situ prepared Zn(II) complexes were studied by NMR spectroscopy, while the stoichiometry of the Cu(II) complexes in solution was determined by UV-Vis titrations and confirmed by the electronic structure DFT calculations at the (SMD)/M05-2X/6-31+G(d)/LanL2DZ + ECP level of theory.

Funding

HrZZ IP–2013–11–5596

HrZZ IP- 2014-09-1461

History

Email Address of Submitting Author

Srecko.Kirin@irb.hr

Institution

Ruđer Bošković Institute

Country

Croatia

ORCID For Submitting Author

0000-0002-0500-2422

Declaration of Conflict of Interest

No conflict of interest

Version Notes

Dear M. Jayanthi, thx for your mail. I have uploaded a different version of the manuscript (with no sign of the publisher). I hope this is now good enough. If not, I would appreciate more detailed instructions. With best regards, Srecko Kirin, in the name of the authors

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