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Copper-Catalyzed Asymmetric Umpolung Hydroamination: an Unified Strategy for the Synthesis of Chiral β-Amino Acid and Its Derivatives

preprint
submitted on 03.07.2020 and posted on 06.07.2020 by Tao Xiong, Wei Guan, Qian Zhang, Ge Zhang, Yujie Liang, Tao Qin, Shuyu Liu
Herein,we reported an unified Cu-catalyzed asymmetric umpolung hydroamination, which is capable of direct preparation of a series of beta-amino acid, ester, amide and nitrile in a highly regio- and enantioselective manner, without the requirement of traditional pre-installation of stoichiometric quantities of auxiliaries.

History

Email Address of Submitting Author

xiongt626@nenu.edu.cn

Institution

Northeast Normal University

Country

China

ORCID For Submitting Author

0000-0002-2516-084X

Declaration of Conflict of Interest

The authors declare no competing financial interest.

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