ChemRxiv
These are preliminary reports that have not been peer-reviewed. They should not be regarded as conclusive, guide clinical practice/health-related behavior, or be reported in news media as established information. For more information, please see our FAQs.
1/1
2 files

Copper-Catalyzed Asymmetric Umpolung Hydroamination: an Unified Strategy for the Synthesis of Chiral β-Amino Acid and Its Derivatives

preprint
submitted on 03.07.2020, 04:11 and posted on 06.07.2020, 10:33 by Tao Xiong, Wei Guan, Qian Zhang, Ge Zhang, Yujie Liang, Tao Qin, Shuyu Liu
Herein,we reported an unified Cu-catalyzed asymmetric umpolung hydroamination, which is capable of direct preparation of a series of beta-amino acid, ester, amide and nitrile in a highly regio- and enantioselective manner, without the requirement of traditional pre-installation of stoichiometric quantities of auxiliaries.

History

Email Address of Submitting Author

xiongt626@nenu.edu.cn

Institution

Northeast Normal University

Country

China

ORCID For Submitting Author

0000-0002-2516-084X

Declaration of Conflict of Interest

The authors declare no competing financial interest.

Exports