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submitted on 03.07.2020 and posted on 06.07.2020by Tao Xiong, Wei Guan, Qian Zhang, Ge Zhang, Yujie Liang, Tao Qin, Shuyu Liu
Herein,we reported an unified Cu-catalyzed asymmetric umpolung hydroamination, which is capable of direct preparation of a series of beta-amino acid, ester, amide and nitrile in a highly regio- and enantioselective manner, without the requirement of traditional pre-installation of stoichiometric quantities of auxiliaries.