These are preliminary reports that have not been peer-reviewed. They should not be regarded as conclusive, guide clinical practice/health-related behavior, or be reported in news media as established information. For more information, please see our FAQs.
DavidSupramolPlasticityMan+SI final.pdf (10.04 MB)

Controlling Supramolecular Plasticity through Stoichiometry

submitted on 01.11.2019, 08:35 and posted on 07.11.2019, 21:43 by David Komaromy, Theodora Tiemersma-Wegman, Johan Kemmink, Giuseppe Portale, Friso Aalbers, Ivana Marić, Guillermo Monreal Santiago, Jim Ottelé, Ankush Sood, Vittorio Saggiomo, Bin Liu, Pieter van der Meulen, Sijbren Otto
In this manuscript we describe how, by taking a systems approach, complex energy landscapes of supramolecular assemblies can be navigated using stoichiometry to control, with remarkable selectivity, which assembly gets populated. The perhaps counterintuitive finding is that it is not necessarily the assembly that, in a one-to-one comparison, is the most stable that wins the competition for common building blocks, even though the system is under thermodynamic control. Instead, an individually less stable assembly may completely dominate the system. This domination is possible when the building block stoichiometry in the system matches the stoichiometry of this specific assembly, allowing the system to maximize binding energy by making a large number of assemblies of moderate stability as opposed to a small number of more stable assemblies.


Email Address of Submitting Author


University of Groningen


The Netherlands

ORCID For Submitting Author


Declaration of Conflict of Interest

No conflict of interest