ChemRxiv
These are preliminary reports that have not been peer-reviewed. They should not be regarded as conclusive, guide clinical practice/health-related behavior, or be reported in news media as established information. For more information, please see our FAQs.
ChemRxivSubmission.pdf (4.89 MB)
0/0

Controlling Nanoemulsion Surface Chemistry with Poly(2-Oxazoline) Amphiphiles

preprint
submitted on 06.09.2018 and posted on 06.09.2018 by Daniel A. Estabrook, Amanda F. Ennis, Rachael Day, Ellen Sletten
Emulsions are dynamic materials that have been extensively employed within pharmaceutical, food and cosmetics industries. However, their use beyond conventional applications has been hindered by difficulties in surface functionalization, and an inability to selectively control physicochemical properties. Here, we employ custom poly(2-oxazoline) block copolymers to overcome these limitations. We demonstrate that poly(2-oxazoline) copolymers can effectively stabilize nanoscale droplets of hydrocarbon and perfluorocarbon in water. The living polymerization allows for the incorporation of chemical handles into the surfactants such that covalent modification of the emulsion surfaces can be performed. Through post-emulsion modification, we are able to access nanoemulsions with modified surface chemistries, yet consistent sizes. By decoupling size and surface charge, we explore structure-activity relationships involving the cellular uptake of nanoemulsions.

Funding

UCLA; NSF MRI CHE-1048804; NIH 5T32GM067555-12

History

Email Address of Submitting Author

sletten@chem.ucla.edu

Institution

University of California Los Angeles

Country

USA

ORCID For Submitting Author

0000-0002-0049-7278

Declaration of Conflict of Interest

No conflicts of interest

Exports