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Controlled Release of Ibuprofen from Polymeric Nanoparticles
preprintsubmitted on 20.09.2019, 08:18 and posted on 24.09.2019, 21:46 by Sara Shehata, Christopher Serpell, Stefano Biagini
Smart polymeric systems are required that are able to release a therapeutic drug with controlled delivery. Herein we investigated the pH triggered release of ibuprofen from a polymeric nanoparticle system prepared using ring-opening metathesis polymerisation. The co-polymerisation of ibuprofen and poly(ethylene)glycol monomers followed by self-assembly produced a nanoparticle system that was shown to be stable at neutral pH but releases ibuprofen in alkaline conditions