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Controlled Release of Ibuprofen from Polymeric Nanoparticles

preprint
submitted on 20.09.2019, 08:18 and posted on 24.09.2019, 21:46 by Sara Shehata, Christopher Serpell, Stefano Biagini
Smart polymeric systems are required that are able to release a therapeutic drug with controlled delivery. Herein we investigated the pH triggered release of ibuprofen from a polymeric nanoparticle system prepared using ring-opening metathesis polymerisation. The co-polymerisation of ibuprofen and poly(ethylene)glycol monomers followed by self-assembly produced a nanoparticle system that was shown to be stable at neutral pH but releases ibuprofen in alkaline conditions

Funding

School of Physical Sciences, University of Kent Graduate Training Scheme, and the EPSRC Doctoral Training Programme

History

Email Address of Submitting Author

s.biagini@kent.ac.uk

Institution

University of Kent

Country

United Kingdom

ORCID For Submitting Author

0000-0002-4713-5127

Declaration of Conflict of Interest

No conflict of interest

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