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Confounding contaminants in mass spectrometric reaction monitoring

preprint
revised on 26.02.2019 and posted on 27.02.2019 by Gilian T. Thomas, Landon MacGillivray, Natalie L. Dean, Rhonda L. Stoddard, Lars Yunker, J Scott McIndoe

Reactions carried out in the presence of rubber septa run the risk of additives being leached out by the solvent. Normally, such species are present at low enough levels that they do not interfere with the reaction significantly. However, when studying reactions using sensitive methods such as mass spectrometry, the appearance of even trace amounts of material can confuse dynamic analyses of reactions. A wide variety of additives are present in rubber along with the polymer: antioxidants, dyes, detergent, and vulcanization agents, and these are all especially problematic in negative ion mode. A redesigned Schlenk flask for pressurized sample infusion (PSI) is presented as a means of practically eliminating the presence of contaminants during reaction analyses.

Funding

NSERC Discovery

History

Email Address of Submitting Author

mcindoe@uvic.ca

Institution

University of Victoria

Country

Canada

ORCID For Submitting Author

0000-0001-7073-5246

Declaration of Conflict of Interest

no conflict of interest

Version Notes

Pre-submission

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in International Journal of Mass Spectrometry

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