ChemRxiv
These are preliminary reports that have not been peer-reviewed. They should not be regarded as conclusive, guide clinical practice/health-related behavior, or be reported in news media as established information. For more information, please see our FAQs.
1/1
2 files

Comprehensive Non-Targeted Analysis of the Prenatal Exposome Reveals Significant Differences in Chemical Enrichment Between Maternal and Fetal Samples

preprint
submitted on 14.10.2020 and posted on 16.10.2020 by Dimitri Abrahamsson, Aolin Wang, Ting Jiang, Miaomiao Wang, Aditya Siddharth, Rachel Morello-Frosch, June-Soo Park, Marina Sirota, Tracey J. Woodruff
The exposome has been recognized as an important dimension in understanding human disease and complementing the genome but remains largely uncharacterized. We analyzed 295 matched maternal and cord blood samples using non-targeted high-resolution mass spectrometry and characterized exposome features. We compared the chemical enrichment of the maternal and cord blood samples using a similarity network analysis and examined the interactions between the exogenous and the endogenous chemical features using a molecular interaction networks approach. We detected over 700 chemical features in the maternal and cord pairs and we found that maternal samples are more similar in terms of chemical enrichment to their corresponding cord samples compared to other maternal samples or other cord samples. We observed significant associations between 3 poly/perfluoroalkyl substances (PFAS) and endogenous fatty acids in both the maternal and cord samples indicating important interactions between PFAS and fatty acid regulating proteins. To our knowledge, this is the first non-targeted analysis study that uses such large cohort to characterize the prenatal exposome.

Funding

Cumulative Effects of Prenatal Stress and Chemical Exposures on Child Development

Office of the Director

Find out more...

The UCSF Pregnancy Exposures to Environmental Chemicals (PEEC) Children's Center

National Institute of Environmental Health Sciences

Find out more...

Discovery of novel environmental chemicals in a diverse population of maternal-infant pairs

National Institute of Environmental Health Sciences

Find out more...

EPA - RD83543301

History

Email Address of Submitting Author

dimitri.abrahamsson@ucsf.edu

Institution

University of California, San Francisco

Country

United States

ORCID For Submitting Author

0000-0002-3402-7565

Declaration of Conflict of Interest

The authors declare no conflict of interest

Exports