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Compaction of RNA Hairpins and Their Kissing Complexes in Native Electrospray Mass Spectrometry
preprintrevised on 17.08.2020, 10:57 and posted on 17.08.2020, 12:54 by Joséphine Abi-Ghanem, Clémence Rabin, Massimiliano Porrini, Frédéric Rosu, Valerie Gabelica
When electrosprayed from typical native MS solution conditions, RNA hairpins and kissing complexes acquire charge states at which they get significantly more compact in the gas phase than their initial structure in solution. Here we show the limits of using force field molecular dynamics to interpret the gas-phase structures of nucleic acid complexes in the gas phase, and we suggest that higher-level calculation levels should be used in the future.
Email Address of Submitting Authorv.email@example.com
ORCID For Submitting Author0000-0001-9496-0165
Declaration of Conflict of InterestThere is no conflict of interest to declare
Version NotesAugust 17, 2020: third revisions
Read the published paper
in Journal of the American Society for Mass Spectrometry