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Combined Use of Amentoflavone and Ledipasvir Could Interfere with Binding of Spike Glycoprotein of SARS-CoV-2 to ACE2: The Results of Molecular Docking Study

preprint
submitted on 27.05.2020 and posted on 29.05.2020 by Kateryna Miroshnychenko, Anna V. Shestopalova

In this study we used molecular docking method to test 248 drugs related to the virus research against spike glycoprotein of SARS-CoV-2. For ten top-ranked drugs the binding sites and interactions with spike glycoprotein were analyzed in detail. The best-scored ligand is the natural biflavonoid amentoflavone. Nine of twelve top-ranked ligands are drugs used for hepatitis C treatment. Among them are ledipasvir, paritaprevir, elbasvir, simeprevir, velpatasvir, glecaprevir and pibrentasvir. The two first-ranked ligands (amentoflavone and ledipasvir) have different binding sites, so their combined use may be effective, but the careful testing is required. We encourage other researchers to explore the combination of amentoflavone and ledipasvir against SARS-CoV-2 in vitro and in vivo.

History

Email Address of Submitting Author

kateryna.miroshnychenko@gmail.com

Institution

O.Ya. Usikov Institute for Radiophysics and Electronics of NAS of Ukraine

Country

Ukraine

ORCID For Submitting Author

0000-0002-2543-6519

Declaration of Conflict of Interest

The authors declare that there is no conflict of interest.

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