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AcylAzolium_Alkylation.pdf (1.22 MB)
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Combined Photoredox and Carbene Catalysis for the Synthesis of Ketones from Carboxylic Acids

preprint
submitted on 10.01.2020 and posted on 13.01.2020 by Anna Davies, keegan fitzpatrick, Rick Betori, Karl Scheidt
Disclosed herein is the development of a novel single-electron reduction of acyl azoliums for the formation of ketones from carboxylic acids. Facile construction of the acyl azolium in situ followed by a radical-radical coupling was made possible using merged NHC-photoredox catalysis. The utility of this protocol in synthesis was demonstrated in the late-stage functionalization of a variety of pharmaceutical compounds.

History

Email Address of Submitting Author

scheidt@northwestern.edu

Institution

Northwestern University

Country

USA

ORCID For Submitting Author

0000-0003-4856-3569

Declaration of Conflict of Interest

No COI

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in Angewandte Chemie International Edition

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