These are preliminary reports that have not been peer-reviewed. They should not be regarded as conclusive, guide clinical practice/health-related behavior, or be reported in news media as established information. For more information, please see our FAQs.
Combined Photoredox and Carbene Catalysis for the Synthesis of Ketones from Carboxylic Acids
preprintsubmitted on 10.01.2020, 21:30 and posted on 13.01.2020, 10:25 by Anna Davies, keegan fitzpatrick, Rick Betori, Karl Scheidt
Disclosed herein is the development of a novel single-electron reduction of acyl azoliums for the formation of ketones from carboxylic acids. Facile construction of the acyl azolium in situ followed by a radical-radical coupling was made possible using merged NHC-photoredox catalysis. The utility of this protocol in synthesis was demonstrated in the late-stage functionalization of a variety of pharmaceutical compounds.
Email Address of Submitting Authorscheidt@northwestern.edu
ORCID For Submitting Author0000-0003-4856-3569
Declaration of Conflict of InterestNo COI
Read the published paper
in Angewandte Chemie International Edition