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Coding Synthetic Chemistry Strategies into Bacterial Designer Cells

submitted on 10.05.2021, 11:58 and posted on 11.05.2021, 10:49 by Yu-Chang Liu, Zhong-Liu Wu, Jan Deska

Following a synthetic chemistry blueprint for the valorization of lignocellulosic platform chemicals, this study showcases a so far unprecedented approach to implement non-natural enzyme modules in vivo. For the design of a novel functional whole cell tool, two purely abiotic transformations were incorporated into a recombinant bacterial host that allows production of complex lactone building blocks. This whole cell system streamlines the synthetic cascade, eliminates isolation and purification steps, and provides a high degree stereoselectivity that has so far been elusive in the chemical methodology.


Beyond Biosynthesis: Enzymes as Catalysts in Non-natural Synthetic Transformations

Academy of Finland

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CEVALOR – Cellular factories for the valorization of biorefinery chemicals

Academy of Finland

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Biosynthetic production of complex lactone building blocks utilizing non-natural enzymatic modules

Novo Nordisk Foundation

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Email Address of Submitting Author


Aalto University, Department of Chemistry



ORCID For Submitting Author


Declaration of Conflict of Interest

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.