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Cobalt Catalysis Enables Regioselective Ring-opening of Epoxides with Aryl Halides
preprintsubmitted on 12.01.2021, 08:19 and posted on 13.01.2021, 07:13 by Aleksandra Potrząsaj, Mateusz Musiejuk, Wojciech Chaładaj, Maciej Giedyk, Dorota Gryko
Ring-opening of epoxides furnishing either linear or branched products belongs to the group of classic transformations in organic synthesis. However, the regioselective cross-electrophile coupling of aryl epoxides with aryl halides still represents a key challenge. Herein, we report vitamin B12/Ni dual-catalytic system that allows for the selective synthesis of linear products under blue-light irradiation.