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Cobalt Catalysis Enables Regioselective Ring-opening of Epoxides with Aryl Halides

preprint
submitted on 12.01.2021, 08:19 and posted on 13.01.2021, 07:13 by Aleksandra Potrząsaj, Mateusz Musiejuk, Wojciech Chaładaj, Maciej Giedyk, Dorota Gryko
Ring-opening of epoxides furnishing either linear or branched products belongs to the group of classic transformations in organic synthesis. However, the regioselective cross-electrophile coupling of aryl epoxides with aryl halides still represents a key challenge. Herein, we report vitamin B12/Ni dual-catalytic system that allows for the selective synthesis of linear products under blue-light irradiation.

Funding

FNP TEAM POIR.04.04.00–00–4232/17–00

National Science Centre, SONATA 2018/31/D/ST5/00306

Wroclaw Centre for Networking and Supercomputing (http://wcss.pl), grant No. 518

History

Email Address of Submitting Author

dorota.gryko@icho.edu.pl

Institution

Institute of Organic Chemistry PAS

Country

Warsaw

ORCID For Submitting Author

0000-0002-5197-4222

Declaration of Conflict of Interest

Authors declare no conflict of interest

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