These are preliminary reports that have not been peer-reviewed. They should not be regarded as conclusive, guide clinical practice/health-related behavior, or be reported in news media as established information. For more information, please see our FAQs.
2 files

Cobalt-Catalyzed Intermolecular [2+2+2] Cycloaddition of Nitriles and Alkynes: Facile Synthesis of Polyarylpyridines and Their Mechanochemical Cyclodehydrogenation to Nitrogen-Containing Polyaromatics

submitted on 21.12.2020, 02:50 and posted on 22.12.2020, 13:07 by Chang-Sheng Wang, Qiao Sun, Felipe Garcia, Chen Wang, Naohiko Yoshikai
Simple, inexpensive and robust cobalt-based catalytic systems for the [2+2+2] cycloaddition between unactivated nitriles and diarylacetylenes are reported. The present systems tolerate a broad range of aryl and alkyl nitriles and cyanamides as well as various di(hetero)arylacetylenes, allowing for the facile preparation of diverse polyarylated pyridines. Mechanochemistry-enabled multifold cyclodehydrogenation of tetra- and pentaarylpyridine is demonstrated to achieve the synthesis of nitrogen-containing polycyclic aromatic compounds having hitherto unprecedented skeletons.


Singapore Ministry of Education Academic Research Fund Tier 2 (MOE2016-T2-2-043 to N.Y.) and Tier 1 (RG114/18 to N.Y.)

Zhejiang Provincial Natural Science Foundation of China (Grant LY18B020007 to C.W.)

A*STAR (AME IRG A1783c0003 to F.G.)


Email Address of Submitting Author


Nanyang Technological University



ORCID For Submitting Author


Declaration of Conflict of Interest

The authors declare that there is no conflict of interest.