These are preliminary reports that have not been peer-reviewed. They should not be regarded as conclusive, guide clinical practice/health-related behavior, or be reported in news media as established information. For more information, please see our FAQs.
Cobalt-Catalyzed Intermolecular [2+2+2] Cycloaddition of Nitriles and Alkynes: Facile Synthesis of Polyarylpyridines and Their Mechanochemical Cyclodehydrogenation to Nitrogen-Containing Polyaromatics
preprintsubmitted on 21.12.2020, 02:50 and posted on 22.12.2020, 13:07 by Chang-Sheng Wang, Qiao Sun, Felipe Garcia, Chen Wang, Naohiko Yoshikai
Simple, inexpensive and robust cobalt-based catalytic systems for the [2+2+2] cycloaddition between unactivated nitriles and diarylacetylenes are reported. The present systems tolerate a broad range of aryl and alkyl nitriles and cyanamides as well as various di(hetero)arylacetylenes, allowing for the facile preparation of diverse polyarylated pyridines. Mechanochemistry-enabled multifold cyclodehydrogenation of tetra- and pentaarylpyridine is demonstrated to achieve the synthesis of nitrogen-containing polycyclic aromatic compounds having hitherto unprecedented skeletons.