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Co-crystals of Praziquantel: Discovery by Network-Based Link Prediction

preprint
submitted on 12.01.2021, 18:42 and posted on 13.01.2021, 12:37 by Jan-Joris Devogelaer, Maxime D. Charpentier, Arnoud Tijink, Valérie Dupray, Gérard Coquerel, Karen Johnston, Hugo Meekes, Paul Tinnemans, Elias Vlieg, Joop H. ter Horst, Rene de Gelder
In this study, co-crystals for Praziquantel (PZQ), an anthelmintic drug used to treat schistosomiasis, are predicted with network-based link prediction. Single crystals of twelve co-crystal indications were grown and subjected to a structural analysis with single-crystal X-ray diffraction.

Funding

Continuous Resolution and Deracemization of Chiral Compounds by Crystallization

European Commission

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History

Email Address of Submitting Author

j.devogelaer@science.ru.nl

Institution

Radboud University

Country

The Netherlands

ORCID For Submitting Author

0000-0001-9533-2590

Declaration of Conflict of Interest

No conflict of interest

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