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MG_Co-crystallization_induced_spontaneous_deracemization_A_General_innovative_thermodynamic_approach_to_deracemization..pdf (4.78 MB)

Co-Crystallization Induced Spontaneous Deracemization: A General Innovative Thermodynamic Approach to Deracemization.

submitted on 17.02.2020, 14:08 and posted on 19.02.2020, 13:04 by michael guillot, josephine demeester, sarah huynen, laurent collard, koen robeyns, olivier riant, Tom Leyssens
Processes leading to enantiopure compounds are of utmost importance, in particular for the pharmaceutical industry. Starting from a racemic mixture, Crystallization Induced Diastereomeric Transformation allows for a theoretical 100% transformation of the desired enantiomer. However, this method has the inherent limiting requirement for the organic compound to form a salt. In this contribution, this limitation is lifted by introducing cocrystallization in the context of thermodynamic deracemization, with the process applied to a model chiral fungicide. We here report a new general single thermodynamic deracemization process based on co-crystallization for the deracemization of (R,S)-4,4-dimethyl1-(4-fluorophenyl)-2-(1H-1,2,4-triazol-1-yl)-Pentan-3-one. This work presents the feasibility of this novel approach and paves the way to further development of such processes.


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Université Catholique de Louvain



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