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ShuoFueledReplicManuscrAndSI.pdf (2.45 MB)
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Chemical Fueling Enables Molecular Complexification of Assembly-Driven Self-Replicators

preprint
submitted on 21.04.2020 and posted on 22.04.2020 by Gael Schaeffer, Elio Mattia, Omer Markovitch, Kai Liu, Andreas S. Hussain, Jim Ottelé, Ankush Sood, Sijbren Otto
This work addressed how self-replicating molecules can evolve to become more complex. Subjecting a system in which two self-replicating molecules compete for a common food source to a regime in which they are both degraded leads to survival of the most complex of the two replicators, even though this replicator is less efficient at replicating. These results show that chemical fueling of a replication process can drive the complexification of the replicator. The more complex replicator is also more proficient at catalyzing a model reaction, showing that complexification can also enhance (catalytic) function.

History

Email Address of Submitting Author

s.otto@rug.nl

Institution

University of Groningen

Country

Netherlands

ORCID For Submitting Author

0000-0003-0259-5637

Declaration of Conflict of Interest

No conflicts of interest

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