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Characterization of reactive organometallic species via MicroED

preprint
revised on 02.04.2019, 20:13 and posted on 02.04.2019, 20:17 by Christopher Jones, Matthew Asay, Lee Joon Kim, Jack Kleinsasser, Ambarneil Saha, Tyler J. Fulton, Kevin Berkley, Duilio Cascio, Andrey Malyutin, Matthew Conley, Brian M. Stoltz, Vincent LaVallo, Jose A. Rodriguez, Hosea Nelson
Here we apply microcrystal electron diffraction (MicroED) to the structural determination of transition metal complexes. We find that the simultaneous use of 300 keV electrons, very low electron doses, and an ultra-sensitive camera allows for the collection of data without cryogenic cooling of the stage. This technique reveals the first crystal structures of the classic zirconocene hydride, colloquially known as “Schwartz’s reagent”, a novel Pd(II) complex not amenable to solution-state NMR or X-ray crystallography, and five other paramagnetic or diamagnetic transition metal complexes.

Funding

NSF DGE-1650604

NSF DMR-1548924

Arnold and Mabel Beckman Foundation

Pew Charitable Trusts

Searle Scholars Program

DOE DE-FC02-02ER63421

NIH P41 GM102403

NIH R35 GM128867

NIH (R35 GM128936-02

David and Lucile Packard Foundation

Alfred P. Sloan Foundation

History

Email Address of Submitting Author

hosea@chem.ucla.edu

Institution

UCLA

Country

USA

ORCID For Submitting Author

0000-0002-4666-2793

Declaration of Conflict of Interest

none

Exports