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EmergentCat Manuscript+SI ChemRxiv.pdf (1.72 MB)

Chance Emergence of Catalytic Activity and Promiscuity in a Self-Replicator

submitted on 18.10.2019, 11:38 and posted on 22.10.2019, 21:36 by Jim Ottelé, Andreas S. Hussain, clemens mayer, Sijbren Otto
This study reveal a mechanism by which self-replicating molecules can autonomously acquire the ability to catalyze further reaction, in addition to their own formation. It represents a first demonstration outside biology of replicators that have the ability to catalyze reactions that produce the molecules they need to replicate from. This equates to a protometabolism.


Email Address of Submitting Author


University of Groningen


The Netherlands

ORCID For Submitting Author


Declaration of Conflict of Interest

no conflict of interest