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Catalytic Asymmetric Reductive Alkylation of Enamines to Chiral Aliphatic Amines

preprint
submitted on 16.10.2020 and posted on 16.10.2020 by Jia-Wang Wang, Yan Li, Wan Nie, Zhe Chang, Zi-An Yu, Yi-Fan Zhao, Xi Lu, Yao Fu

Herein, we report a mild and general nickel-catalysed asymmetric reductive alkylation to effectively convert enamines—a class of important yet underexploited feedstock chemicals—into drug-like α-branched chiral amines and derivatives. This reaction involves the regio- and stereoselective hydrometallation of an enamine to generate a catalytic amount of enantioenriched alkylnickel intermediate, followed by C–C bond formation via alkyl electrophiles.

History

Email Address of Submitting Author

luxi@mail.ustc.edu.cn

Institution

University of Science and Technology of China

Country

China

ORCID For Submitting Author

0000-0002-9338-0780

Declaration of Conflict of Interest

The authors declare no competing financial interest.

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